Chuan Wu et al 2003 Phys. Med. Biol. 48 2479 doi:10.1088/0031-9155/48/15/315
Chuan Wu1, Gustavo H Olivera2,3, Robert Jeraj2,3,4, Harry Keller2 and Thomas R Mackie2,3
Show affiliationsUnder various clinical situations, it is desirable to modify the original treatment plan to better suit the clinical goals. In this work, a method to help physicians modify treatment plans based on their clinical preferences is proposed. The method uses a weighted quadratic dose objective function. The commonly used organ-/ROI-based weighting factors are expanded to a set of voxel-based weighting factors in order to obtain greater flexibility in treatment plan modification. Two different but equivalent modification schemes based on Rustem's quadratic programming algorithms—modification of a weighting matrix and modification of prescribed doses—are presented. Case studies demonstrated the effectiveness of the two methods with regard to their capability to fine-tune treatment plans.
Issue 15 (7 August 2003)
Received 11 February 2003, in final form 12 May 2003
Published 22 July 2003
Chuan Wu et al 2003 Phys. Med. Biol. 48 2479
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