Andrew L Goertzen et al 2002 Phys. Med. Biol. 47 4315 doi:10.1088/0031-9155/47/24/301
Andrew L Goertzen1,2,3, A Ken Meadors1, Robert W Silverman1 and Simon R Cherry2
Show affiliationsNon-invasive imaging technologies are opening up new windows into mouse biology. We have developed a mouse imaging system that integrates positron emission tomography (PET) with x-ray computed tomography (CT), allowing simultaneous anatomic and molecular imaging in vivo with the potential for precise registration of the two image volumes. The x-ray system consists of a compact mini-focal x-ray tube and an amorphous selenium flat panel x-ray detector with a low-noise CMOS readout. The PET system uses planar arrays of lutetium oxyorthosilicate scintillator coupled to position-sensitive photomultiplier tubes. We describe the design of this dual-modality imaging system and show, for the first time, simultaneously acquired PET and CT images in a phantom and in mice.
87.57.uk Positron emission tomography (PET)
Issue 24 (21 December 2002)
Received 18 July 2002
Published 3 December 2002
Andrew L Goertzen et al 2002 Phys. Med. Biol. 47 4315
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