Nadir Zeghib and Daniel Grucker 2001 Phys. Med. Biol. 46 2371 doi:10.1088/0031-9155/46/9/307
Nadir Zeghib and Daniel Grucker
Show affiliationsDynamic nuclear polarization (DNP) of water protons was used to measure the relaxation time of lithium at very low magnetic field as a demonstration of the use of DNP for nuclei less abundant than water protons. Lithium (Li+) was chosen because it is an efficient treatment for manic-depressive illness, with an unknown action mechanism. After having recalled the theoretical basis of a three-spin system comprising two nuclei—the water proton of the solvent, the dissolved Li+ ion and the free electron of a free radical—we have developed a transient solution in order to optimize potential biological applications of Li DNP. The three-spin model has allowed computation of all the parameters of the system—the longitudinal relaxation rate per unit of free radical concentration, the dipolar and scalar part of the coupling between the nuclei and the electron, and the maximum signal enhancement achievable for both proton and lithium spins. All these measurements have been obtained solely through the detection of the proton resonance.
Issue 9 (September 2001)
Received 11 May 2001
Published 3 August 2001
Nadir Zeghib and Daniel Grucker 2001 Phys. Med. Biol. 46 2371
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