Elizabeth M C Hillman et al 2001 Phys. Med. Biol. 46 1117 doi:10.1088/0031-9155/46/4/315
Elizabeth M C Hillman1, Jeremy C Hebden1, Martin Schweiger1, Hamid Dehghani1, Florian E W Schmidt1, David T Delpy1 and Simon R Arridge2
Show affiliationsA 32-channel time-resolved optical imaging instrument has been developed principally to study functional parameters of the new-born infant brain. As a prelude to studies on infants, the device and image reconstruction methodology have been evaluated on the adult human forearm. Cross-sectional images were generated using time-resolved measurements of transmitted light at two wavelengths. All data were acquired using a fully automated computer-controlled protocol. Images representing the internal scattering and absorbing properties of the arm are presented, as well as images that reveal physiological changes during a simple finger flexion exercise. The results presented in this paper represent the first simultaneous tomographic reconstruction of the internal scattering and absorbing properties of a clinical subject using purely temporal data, with additional co-registered difference images showing repeatable absorption changes at two wavelengths in response to exercise.
Issue 4 (April 2001)
Received 25 September 2000
Elizabeth M C Hillman et al 2001 Phys. Med. Biol. 46 1117
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