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99Tcm radio-pharmaceuticals for the X-ray fluorescence assessment of gold in vivo

J Shakeshaft, S Lillicrap and M Evans

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From the work presented it is concluded that intravenously administered 99Tcm radiolabelled pharmaceuticals would be suitable sources for X-ray fluorescence (XRF) studies of gold in the kidney. The target minimum detectable level of 50 mu g g-1 would be achieved with a detector of sufficient area using significantly less than the activity administered to patients undergoing diagnostic renal studies. Of the two radio-pharmaceuticals in routine use locally for kidney studies, DMSA proved to be the better drug, as to obtain the same XRF yield higher activities of DTPA need to be administered.


PACS

87.57.un Radiopharmaceuticals

87.64.K- Spectroscopy

Subjects

Biological physics

Medical physics

Dates

Issue 4 (April 1991)



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