P N Brown et al 1985 Phys. Med. Biol. 30 1113 doi:10.1088/0031-9155/30/10/010
P N Brown, P C Jackson, G E Staddon, R B Richardson and H B Griffith
Show affiliationsA mathematical model of the cerebrospinal fluid (CSF) flow dynamics found in hydrocephalic infants with myelomeningocele lesions was constructed using criteria obtained from analogous clinical situations where 125I-labelled and 131I-labelled ortho-iodo-benzoyl-amino-acetic acid (hippuran) had been employed to measure CSF flow dynamics. The quantitative results from this study allowed clinical data to be assessed and the importance of various CSF transfer mechanisms to be discussed. The mathematical model indicates that the majority of radiopharmaceutical passes from the cerebral reservoir (the ventricles) into the blood. Experimental evidence indicates that the principal mechanism responsible for this movement is the bulk flow of CSF between its sites of production in the choroid plexus and absorption by the arachnoid villi.
Issue 10 (October 1985)
P N Brown et al 1985 Phys. Med. Biol. 30 1113
Hongseok Choi et al 2007 J. Micromech. Microeng. 17 2248
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