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Compartmental analysis of cerebrospinal fluid transfer and absorption in simulated hydrocephalus

P N Brown, P C Jackson, G E Staddon, R B Richardson and H B Griffith

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A mathematical model of the cerebrospinal fluid (CSF) flow dynamics found in hydrocephalic infants with myelomeningocele lesions was constructed using criteria obtained from analogous clinical situations where 125I-labelled and 131I-labelled ortho-iodo-benzoyl-amino-acetic acid (hippuran) had been employed to measure CSF flow dynamics. The quantitative results from this study allowed clinical data to be assessed and the importance of various CSF transfer mechanisms to be discussed. The mathematical model indicates that the majority of radiopharmaceutical passes from the cerebral reservoir (the ventricles) into the blood. Experimental evidence indicates that the principal mechanism responsible for this movement is the bulk flow of CSF between its sites of production in the choroid plexus and absorption by the arachnoid villi.


PACS

87.57.un Radiopharmaceuticals

87.19.L- Neuroscience

47.63.-b Biological fluid dynamics

87.19.U- Hemodynamics

Subjects

Fluid dynamics

Biological physics

Medical physics

Dates

Issue 10 (October 1985)



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