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An application of combining results from multiple methods—statistical evaluation of uncertainty for NIST SRM 1508a

A Hornikova1, N F Zhang1, M J Welch2 and S Tai2

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NIST standard reference materials (SRMs) are certified reference materials that are developed at NIST and provided to laboratories (industry, government and academia) for assessment and improvement of measurement quality. This paper details the statistical analysis related to the recertification of SRM 1508a, benzoylecgonine (cocaine metabolite) in freeze-dried urine, to incorporate new data. The recertification is based on combining measurement results from different measurement methods and time periods. Several different statistical models and corresponding estimators were considered for the certified value, its standard uncertainty and its expanded uncertainty.


PACS

82.80.Bg Chromatography

06.20.Dk Measurement and error theory

02.50.-r Probability theory, stochastic processes, and statistics

82.80.Ms Mass spectrometry (including SIMS, multiphoton ionization and resonance ionization mass spectrometry, MALDI)

Subjects

Computational physics

Instrumentation and measurement

Chemical physics and physical chemistry

Dates

Issue 3 (June 2006)

Received 21 July 2005

Published 28 February 2006



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