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Some aspects of pharmaceutical analysis using high performance liquid chromatography

M J Cope and I E Davidson

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The history and general principles of high performance liquid chromatography are reviewed. Liquid chromatographic theory and the various modes of chromatography are discussed, including adsorption, partition, reversed phase and ion-exchange modes. Equipment used in pharmaceutical analysis is described including pumping systems, mobile phases, sample introduction systems, columns and column fittings, detectors and data handling systems. Applications are reviewed, with particular reference to antibiotic analysis, optical isomer resolution, biopharmaceutical analysis and pharmaceutical production. Future developments are considered, including column technology, detector development, automation and the analysis of biopolymers.


PACS

82.80.Bg Chromatography

87.80.-y Biophysical techniques (research methods)

Subjects

Instrumentation and measurement

Medical physics

Biological physics

Chemical physics and physical chemistry

Dates

Issue 10 (October 1986)



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