M J Cope and I E Davidson 1986 J. Phys. E: Sci. Instrum. 19 763 doi:10.1088/0022-3735/19/10/001
M J Cope and I E Davidson
Show affiliationsThe history and general principles of high performance liquid chromatography are reviewed. Liquid chromatographic theory and the various modes of chromatography are discussed, including adsorption, partition, reversed phase and ion-exchange modes. Equipment used in pharmaceutical analysis is described including pumping systems, mobile phases, sample introduction systems, columns and column fittings, detectors and data handling systems. Applications are reviewed, with particular reference to antibiotic analysis, optical isomer resolution, biopharmaceutical analysis and pharmaceutical production. Future developments are considered, including column technology, detector development, automation and the analysis of biopolymers.
Issue 10 (October 1986)
M J Cope and I E Davidson 1986 J. Phys. E: Sci. Instrum. 19 763
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