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Progress in the preparation of magnetic nanoparticles for applications in biomedicine

REVIEW ARTICLE

A G Roca, R Costo, A F Rebolledo, S Veintemillas-Verdaguer, P Tartaj, T González-Carreño, M P Morales and C J Serna

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TOPICAL REVIEW

This review summarizes recent advances in synthesis routes for quickly and reliably making and functionalizing magnetic nanoparticles for applications in biomedicine. We put special emphasis on describing synthetic strategies that result in the production of nanosized materials with well-defined physical and crystallochemical characteristics as well as colloidal and magnetic properties. Rather than grouping the information according to the synthetic route, we have described methods to prepare water-dispersible equiaxial magnetic nanoparticles with sizes below about 10 nm, sizes between 10 and 30 nm and sizes around the monodomain–multidomain magnetic transition. We have also described some recent examples reporting the preparation of anisometric nanoparticles as well as methods to prepare magnetic nanosized materials other than iron oxide ferrites, for example Co and Mn ferrite, FePt and manganites. Finally, we have described examples of the preparation of multicomponent systems with purely inorganic or organic–inorganic characteristics.


PACS

75.75.+a Magnetic properties of nanostructures

75.50.Tt Fine-particle systems; nanocrystalline materials

75.30.Kz Magnetic phase boundaries (including magnetic transitions, metamagnetism, etc.)

81.07.Bc Nanocrystalline materials

82.70.Dd Colloids

87.85.Qr Nanotechnologies-design

Subjects

Soft matter, liquids and polymers

Condensed matter: electrical, magnetic and optical

Nanoscale science and low-D systems

Chemical physics and physical chemistry

Dates

Issue 22 (21 November 2009)

Received 9 March 2009

Published 6 November 2009



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