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Analysis of skin tissues spatial fluorescence distribution by the Monte Carlo simulation

D Y Churmakov1, I V Meglinski1, S A Piletsky2 and D A Greenhalgh1

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A novel Monte Carlo technique of simulation of spatial fluorescence distribution within the human skin is presented. The computational model of skin takes into account the spatial distribution of fluorophores, which would arise due to the structure of collagen fibres, compared to the epidermis and stratum corneum where the distribution of fluorophores is assumed to be homogeneous. The results of simulation suggest that distribution of auto-fluorescence is significantly suppressed in the near-infrared spectral region, whereas the spatial distribution of fluorescence sources within a sensor layer embedded in the epidermis is localized at an `effective' depth.


PACS

87.14.E- Proteins

87.64.Ee Electron microscopy

02.50.Ng Distribution theory and Monte Carlo studies

87.64.K- Spectroscopy

87.80.-y Biophysical techniques (research methods)

87.16.Nn Motor proteins (myosin, kinesin dynein)

Subjects

Computational physics

Instrumentation and measurement

Medical physics

Biological physics

Dates

Issue 14 (21 July 2003)

Received 4 December 2002, in final form 10 April 2003

Published 1 July 2003



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