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Short pulse laser propagation through tissues for biomedical imaging

Champak Das1, Ashish Trivedi1, Kunal Mitra1,3 and Tuan Vo-Dinh2

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An experimental and numerical study is performed to analyse short pulse laser propagation through tissue phantoms with and without inhomogeneities embedded in it. Short pulse laser probing techniques have distinct advantages over conventional very large pulse width or cw lasers primarily due to the additional information conveyed about the tissue interior by the temporal variation of the observed signal. Both the scattered temporal transmitted and reflected optical signals are measured experimentally using a streak camera for samples irradiated with a short pulse laser source. Parametric study involving different scattering and absorption coefficients of tissue phantoms and inhomogeneities as well as the detector position and orientation is performed. The temporal and spatial profiles of the scattered optical signals are compared with the numerical modelling results obtained by solving the transient radiative transport equation using the discrete ordinates technique.


PACS

87.63.L- Visual imaging

42.60.Pk Continuous operation

87.10.-e General theory and mathematical aspects

42.62.Be Biological and medical applications

Subjects

Biological physics

Optics, quantum optics and lasers

Medical physics

Dates

Issue 14 (21 July 2003)

Received 12 December 2002, in final form 9 April 2003

Published 1 July 2003



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